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In episode 9, Frank embarks on a "bucket list" style spree with Bianca, who has advanced pancreatic cancer.
In season 5, a home beer brewing mishap causes Sheila to leave for good.
After leaving a note for Frank, Bianca commits suicide by walking naked into the ocean.
Frank returns home crying and tells Lip and Ian that Bianca has died.
Frank did attend college to study psychology, where he met Monica.
They had only dated for about 2 weeks before they got married.